Matsumoto Kiyoshi

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MENTIONSVariant: 2% / PDRN 2%M Cure Derma PD Serum 1%
  • “The main ingredients that they talk about on the site are of course the Shinto Gata PDRN or the Hydrolyse PRN, which is made smaller to help penetrate further into the skin”6:54–7:07
  • “You also have retinol, you have niacinamide, which, you know, those are just like the classic people, but those are evidence-based skincare ingredients”7:07–7:15
  • “Copper peptides oh my god you never see that in Jamie this is the first time I think I've seen that in Jamie I'm like wow this is so fascinating”7:25–7:36
  • “I actually used the ordinary copper peptide serum years ago and it was very nice and I really really liked it”7:36–7:41
  • “Niacinamide as the fourth ingredient so realistically I do think that most of the weight is going to be pulled by niacinamide in these products”9:33–9:39
  • “You have things like caffeine which caffeine is also slowly it's like pdr and it's slowly making its way into j beauty”9:45–9:50
  • “Toripeptido is copper and so try peptide one copper copper peptides baby”
  • “My question then would be how would the integrity of these copper peptides be kept in these formulations”11:00–11:06
  • Source: Exciting Japanese skincare products I've seen in a while - Mar 31, 2026
Brand note

Matsumoto Kiyoshi's M Cure line is a Japanese drugstore brand that loads its formulas with trendy, evidence-based ingredients — think PDRN, copper peptides, multiple ceramides, and niacinamide — but the execution raises questions. The M Cure Derma PD Serum 1% packs a dense ingredient list including retinol, niacinamide, and copper peptides, though one creator questions how well those peptides hold up in the formula.