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4.5AlphaRet Overnight Cream
  • “I like that there's a published study that was done on this exact product comparing it to the gold standard retinoid for anti-aging, which is prescription tretinoin”5:08–5:15
  • “At 4, 8, and 12 weeks, the AlphaRet side was non-inferior to tretinoin at improving fine lines, facial redness, facial discoloration, and skin tone”
  • “It was also less irritating than both retinol and tretinoin”
  • “Unlike tretinoin which reduced skin hydration, AlphaRet increased skin hydration”
  • “I really like this product because I have sensitive skin even though I hate how expensive it is”
  • “If I completely ignore prices and I live in La La Land, it is my favorite over-the-counter retinoid”
  • “My sensitive skin tolerates it well”
  • “I like how the color isn't as scary as the stronger retinal's too”
  • Source: Dermatologist: Best Retinoids at Every Price - Mar 14, 2026